Publications

Ma Y, Farny NG+. Connecting the Dots: Neuronal Senescence, Stress Granules, and Neurodegeneration. 2023. GENE.  871:147437. https://doi.org/10.1016/j.gene.2023.147437 

Demetry, C., E.L. Lingo, S.C. Roberts, J. Skorinko, N. Farny, “More than a network: A mid-career mentoring system that values meaningful work,” invited chapter in Breaking the Silence: Institutional Responsibility in Women’s Promotion to Full Professor, Purdue University Press. In Press.

Carrillo Rincón AF, Farny NG+. Unlocking the strength of inducible promoters in gram-negative bacteria. 2023. Microbial Biotechnology. 16961976. https://doi.org/10.1111/1751-7915.14219

Cabral AJ, Costello DC, Farny NG+. The enigma of ultraviolet radiation stress granules: Research challenges and new perspectives. Frontiers in Molecular Biosciences. 2022;9. doi: 10.3389/fmolb.2022.1066650

Yamazaki T+, Audas TE+, Farny NG+. The Why of RNA granules: Form, function, and regulation. (Editorial) Frontiers in Molecular Biosciences. 2022;9. doi: 10.3389/fmolb.2022.1111463

Beal J*, Baldwin GS*, Farny NG*, Gershater M*, Haddock-Angelli T*, Buckley-Taylor R, Dwijayanti A, Kiga D, Lizarazo M, Marken J, de Mora K, Rettberg R, Sanchania V, Selvarajah V, Sison A, Storch M,  Workman CT, the iGEM Interlab Study Contributors. Comparative analysis of three studies measuring fluorescence from engineered bacterial genetic constructs. PloS One. 2021 Jun 7;16(6):e0252263. https://doi.org/10.1371/journal.pone.0252263 (* corresponding authors)

Fay MM, Columbo D, Cotter C, Friend C, Henry SM, Hoppe M, Karabelas P, Lamy C, Lawell M, Monteith S, Noyes C, Salerno P, Wu J, Zhang HM, Anderson PJ, Kedersha N, Ivanov P*, Farny NG*. (2021). Bisphenol A promotes stress granule assembly and modulates the integrated stress response. Biol Open. Jan 10;10(1):bio057539. https://doi.org/10.1242/bio.057539 (* corresponding authors)

Beal J*, Farny NG*, Haddock-Angelli T*, Selvarajah V, Baldwin GS*, Buckley-Taylor R, Gershater M*, Kiga D, Marken J, Sanchania V, Sison A, Workman CT*, and the iGEM Interlab Study Contributors. (2020) Robust estimation of bacterial cell count from optical density. Commun Biol. Sep 17;3(1):1-29. PMID: 32943734 https://doi.org/10.1038/s42003-020-01127-5 (*corresponding authors)

Farny NG. A Vision for Teaching the Values of Synthetic Biology. 2018. Trends Biotechnol. (36)11:1097-1100. https://doi.org/10.1016/j.tibtech.2018.07.019

Beal J , Haddock-Angelli T, Farny N, Rettberg R. Time to get serious about measurement in synthetic biology. Trends Biotechnol. 36(9):869-871. https://doi.org/10.1016/j.tibtech.2018.05.003

Beal J, Haddock-Angelli T, Baldwin G, Gershater M, Dwijayanti A, Storch M , Lizarazo M, Rettberg R, with the iGEM Interlab Study Contributors* Quantification of Bacterial Fluorescence using Independent Calibrants. PLoS One. 13(6):e0199432. https://doi.org/10.1371/journal.pone.0199432  (*Includes Farny N, and WPI undergraduate students Gergits F, Googins M, Martin S, Reames C.)

Beal J , Haddock-Angelli T, Gershater M, de Mora K, Lizarazo M, Hollenhorst J, Rettberg R, iGEM Interlab Study Contributors*. Reproducibility of Fluorescent Expression from Engineered Biological Constructs in E. coli. PLOS One. 2016 Mar 3, 11(3): e0150182. https://doi.org/10.1371/journal.pone.0150182 *(Includes Farny N, and WPI undergraduate students LaJeunesse C, Turland A, DeSanty K, Mazza J.)

Weyn-Vanhentenryck  S, Sun S, Yan Q, Mele A, Farny N, Zhang Z, Silver PA, Zhang MQ, Krainer AR, Darnell RB, Zhang C. HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network l­­inked to brain development and autism. Cell Rep. 2014 Mar 27;6(6):1139-52. https://doi.org/10.1016/j.celrep.2014.02.005

Udagawa T*,  Farny NG*, Jakovcevski M*, Kaphzan H, Alarcon JM, Anilkumar S, Nagaoka K, Ivshina M, Hurt JA, Nalavadi VC, Lorenz LJ, Bassell GJ, Akbarian S, Chattarji S, Klann E, Richter JD.  Genetic and Acute CPEB1 depletion ameliorate Fragile X pathophysiology. ( * these authors contributed equally to this work) Nat Medicine. 2013 Nov; 19(11): 1473-1477. https://doi.org/10.1038/nm.3353

Chen AJ, Paik JH, Zhang H, Shukla SA, Mortensen R, Hu J, Ying H, Hu B, Hurt J, Farny N, Dong C, Xiao Y, Wang YA, Silver PA, Chin L, Vasudevan S, Depinho RA. STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes Dev. 2012 Jul 1;26(13):1459-72. http://www.genesdev.org/cgi/doi/10.1101/gad.189001.112

Farny NG, Kedersha N, Silver PA.  Metazoan stress granule assembly is mediated by P-eIF2alpha-dependent and independent mechanisms. RNA. 2009 Oct;15(10):1814-21. https://doi.org/10.1261/rna.1684009

Hurt JA, Obar RA, Zhai B, Farny NG, Gygi SP, Silver PA. A conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and export. J Cell Biol. 2009 Apr 20;185(2):265-77. https://doi.org/10.1083/jcb.200811072

  • Research Highlight in: Nat Chem Biol. 2009 Jun;5(6):380.

Farny NG*, Hurt JA*, Silver PA. Definition of global and transcript-specific mRNA export pathways in metazoans. Genes Dev. 2008 Jan 1;22(1):66-78. (* these authors contributed equally to this work) https://doi.org/10.1101/gad.1616008

  • Research Highlight in: Nat Rev Mol Cell Biol. 2008 Feb; 9(2):92-93.
  • Featured in: Wolyniak MJ, Cole CN. RNA Biol. 2008 Apr-Jun;5(2):68-72.
  • Cover art featured

Komili S, Farny NG, Roth FP, Silver PA. Functional specificity among ribosomal proteins regulates gene expression. Cell. 2007 Nov 2;131(3):557-71. https://doi.org/10.1016/j.cell.2007.08.037

  • Preview in: Cell. 2007 Nov 2;131(3):450-1.
  • F1000 featured article, rated Exceptional

McEwen E, Kedersha N, Song B, Scheuner D, Gilks N, Han A, Chen JJ, Anderson P, Kaufman RJ.  Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure. J Biol Chem. 2005 Apr 29;280(17):16925-33. https://doi.org/10.1074/jbc.m412882200

Gilks N, Kedersha N, Ayodele M, Shen L, Stoecklin G, Dember LM, Anderson P. Stress granule assembly is mediated by prion-like aggregation of TIA-1. Mol Biol Cell. 2004 Dec;15(12):5383-98. https://doi.org/10.1091/mbc.e04-08-0715

Li W, Kedersha N, Chen S, Gilks N, Lee G, Anderson P. FAST is a BCL-X(L)-associated mitochondrial protein. Biochem Biophys Res Commun. 2004 May 21;318(1):95-102. https://doi.org/10.1016/j.bbrc.2004.03.188

Kedersha N, Chen S, Gilks N, Li W, Miller IJ, Stahl J, Anderson P.  Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules. Mol Biol Cell. 2002 Jan;13(1):195-210. https://doi.org/10.1091/mbc.01-05-0221

Kedersha N, Cho MR, Li W, Yacono PW, Chen S, Gilks N, Golan DE, Anderson P. Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules. J Cell Biol. 2000 Dec 11;151(6):1257-68. https://doi.org/10.1083/jcb.151.6.1257